NEET PG Medical – 2019 – Question – 36
Which apolipoprotein is responsible for Alzeihmers disease
a) APOE4
b) APOE3
c) APOE2
d) APOE1
Show Answer
Correct Answer – A
ANSWER. A. APOE4
Three common polymorphisms in the APOE gene, e2, e3, and e4, result in single amino changes in the ApoE protein.
The e4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer’s disease (AD).
the differential effects of apoE isoforms on Aß aggregation and clearance play the major role in AD pathogenesis.
In particular, APOE e4 is associated with increased risk for AD, whereas APOEe2 is associated with decreased risk.
