NEET PG Medical – 2018 – Question – 61
Which of the following antipsychotic have increased prolactin secretion –
a) Olanzapine
b) Ziprasidone
c) Clozapine
d) Risperidone
Show Answer
Correct Answer – D
Answer:- D – Risperidone
Significant rise in prolactin levels during risperidone therapy is observed.
- Risperidone – Antipsychotic drug with combined 5-HT 2a and dopamine D2 antagonist activity.
- High affinity to alpha1, alpha 2 and H1 receptors.
- More potent D2 blocker than clozapine
- Ameliorates symptoms of schizophrenia
- Prolactin levels rise during risperidone therapy, but less epileptogenic than clozapine.
- Produces extrapyramidal side effects are less only at lower doses (<6 mg/day).
- Blockade of these contribute to efficacy and side effects like postural hypotension.
- Frequently causes agitation.
