Biochemistry – Question 8
Thiamine is not used in which of the following reactions
a) Glucose to pentose
b) Lactate to Pyruvate
c) Oxidative decarboxylation of Alfa-keto amino acids
d) Alfa-ketoglutarate to succinyl Co-A
b) Lactate to Pyruvate
Thiamine Pyrophosphate works as a coenzyme in:
Pyruvate dehydrogenase complex
Pyruvate decarboxylase in ethanol fermentation
Alpha-ketoglutarate dehydrogenase complex
Branched-chain amino acid dehydrogenase complex
2-hydroxyphytanoyl-CoA lyase
Transketolase
Lactate dehydrogenase:
It catalyzes the inter-conversion of pyruvate and lactate with concomitant inter-conversion of NADH and NAD+. Co-enzyme is niacin.
Important point:
Thiamin triphosphate has a role in nerve conduction; it phosphorylates, and so activates a chloride channel in nerve membrane.
Ref: Harper’s Illustrated Biochemistry, 31st Edition and Page-533-34
