Biochemistry – Question 6
Which end product of citric acid cycle is used in detoxification of ammonia in brain?
a) Citrate
b) Succinate
c) Alfa-ketoglutarate
d) Oxaloacetate
Answer and Explanation
c) Alfa-ketoglutarate
Detoxification of ammonia in brain
Glutamine is the sole form of transport of ammonia in brain and the major mechanism for the removal of ammonia in the brain.
Glutamine provides non-toxic storage and transport form of ammonia.
Important point:
Glutamine is an amide of Glutamic acid which is formed from alfa-ketoglutarate.
Ref: Harper’s Illustrated Biochemistry, 31st Edition and Page-272-73
