NEET PG Medical – 2020 – Question – 66
Drug of choice for invasive aspergillosis is
a) Posaconazole
b) Voriconazole
c) Liposomal AMB
d) Caspofungin
Show Answer
Correct Answer – A
Ans: A. Rifampicin
Overall inhibition of RNA synthesis by rifampicin is caused by a destabilizing effect on the binding of the intermediate
oligonucleotides to the active enzyme-DNA complex.
Rifampicin itself can only interact specifically with RNA polymerase if the enzyme is free or in a binary complex with DNA.
Ref: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC327649/
