NEET PG Medical – 2020 – Question – 65
Drug of choice for invasive aspergillosis is
a) Posaconazole
b) Voriconazole
c) Liposomal AMB
d) Caspofungin
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Correct Answer – B
Ans: B. Voriconazole
The preferred treatment of primary IA is voriconazole, which has been found to be superior to amphotericin B.
Azoles interfere with the synthesis of ergosterol found in the fungal cell membrane, whereas polyenes — such as amphotericin B — interfere with ergosterol function.
An echinocandin that disrupts fungal cell wall synthesis – caspofungin — and itraconazole have been approved for salvage
therapy of IA.
Ref: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200583/
