NEET PG Medical – 2019 – Question – 78
Mechanism of action of curare like drugs?
a) Blocks ACh synthesis
b) Blocks ACh receptors
c) Persistent depolarization
d) Agonistic with Ach receptors
Show Answer
Correct Answer – B
Ans. B. Blocks ACh receptors
Tubocurarine, Cisatracurium, Rocuronium: Competitive antagonist at nACh receptors mainly at NM junction.
d-tubocurarine:
- Obsolete clinical usage.
- Prototype NM blocker.
- Longer acting isoquinoline derivative.
- MOA: Acts predominantly at nicotinic receptor site blocking their receptors – By competing with acetylcholine (competitive antagonism).
