NEET PG Medical – 2019 – Question – 73
Which of the following drug is used in SIADH?
a) Tolvapatan
b) Desmopressin
c) Vwb factor
d) Terlipressin
Show Answer
Correct Answer – A
Ans. A. Tolvaptan
Tolvaptan:
* Vasopressin antagonists.
* Orally active nonpeptide selective V2 receptor antagonist.
* Metabolized by CYP3A4 – Not given to patients receiving this isoenzyme inhibitor.
* Given once daily.
* t½: 6–8 hours.
Actions:
* Increases free water clearance by kidney (aquaretic).
* Corrects lower plasma Na+ levels.
Uses:
* Useful for hyponatremia treatment.
* Hyponatremia caused by CHF, cirrhosis of liver or syndrome of inappropriate ADH secretion (SIADH).
Side effect:
* Thirst & dry mouth (most frequent).
* Fever, G.I. upset & hyperglycaemia.
