NEET PG Medical – 2019 – Question – 72
Which among the following is most probable reason for preference of Cisatracurium over atracurium?
a) Decreased histamine release
b) Increased histamine release
c) Due to elimination by Hofmann elimination
d) Increased CNS toxicity
Show Answer
Correct Answer – A
Ans. A. Decreased histamine release
Cisatracurium:
* Undergoes Hofmann elimination.
* Does not provoke histamine release – Hence, preferred over atracurium.
* No effect on heart rate/BP/nil autonomic effect.
* Produces less laudanosine than atracurium – Hence, less CNS toxicity (seizures).
