NEET PG Medical – 2019 – Question – 56
Follicular lymphoma positivity?
a) Bcl-1
b) Bcl-6
c) Bcl- 2
d) None of the above
Show Answer
Correct Answer – C
Answer-C. Bcl-2
A translocation between chromosome 14 and 18 results in the overexpression of the bcl-2 gene. As the bcl-2 protein is normally involved in preventing apoptosis, cells with an overexpression of this protein are basically immortal. The bcl-2 gene is normally found on chromosome 18, and the translocation moves the gene near to the site of the immunoglobulin heavy chain enhancer element on chromosome 14.
