NEET PG Medical – 2019 – Question – 52
Apoptotic gene is
a) Bax
b) Bcl2
c) Bclx
d) Mcl
Show Answer
Correct Answer – B
Answer-B. Bcl2
Regulation is primarily by the Bcl-2 family of genes located on chromosome 18.
Some members of this family like bak, bid, bin, Bcl-xs (to remember, S for stimulating apoptosis) stimulate apoptosis whereas others like Bcl-2, Bcl-xl (to remember, L for lower apoptosis), etc. inhibit apoptosis.
Gene families such as caspases, inhibitor of apoptosis proteins, B cell lymphoma (Bcl)-2 family of genes, tumor necrosis factor (TNF) receptor gene superfamily, or p53 gene are involved, and/or collaborate in the process of apoptosis.
