NEET PG Medical – 2019 – Question – 48
Type-I hyperlipoproteinemia is characterized by
a) Elevated LDL
b) Elevated HDL
c) Elevated chylomicrons
d) Elevated lipoprotein lipase
Correct Answer – C
Answer C. Elevated chylomicrons
Lipoprotein lipase deficiency (Type I hyperlipoproteinemia) results in increased level of chylomicrones.
Lipoprotein lipase deficiency is a genetic disorder in which a person has a defective gene for lipoprotein lipase, which leads to very high triglycerides, which in turn causes stomach pain and deposits of fat under the skin, and which can lead to problems with the pancreas and liver, which in turn can lead to diabetes.
The disorder only occurs if a child acquires the defective gene from both parents (it is autosomal recessive). It is managed by restricting fat in diet to less than 20 g/day.
The disease often presents in infancy with colicky pain, failure to thrive, and other symptoms and signs of the chylomicronemia syndrome.
The condition has also been called familial chylomicronemia syndrome, chylomicronemia, chylomicronemia syndrome. and
hyperlipoproteinem type Ia.
