NEET PG Medical – 2019 – Question – 43
True about type 1 diabetes mellitus
a) Decreased protein catabolism
b) Decreased hepatic Glucose output
c) Increased lipolysis
d) Increase glucose uptake
Correct Answer – C
Answer: C. Increased lipolysis
Uncontrolled insulin-dependent diabetes mellitus (type I diabetes) involves decreased glucose utilization, with hyperglycemia, and increased fatty acid oxidation.
Increased fatty acid oxidation leads to excessive production of acetoacetic and 3-hydroxybutyric acids and of acetone, which are known as ketone bodies.
2. Acetoacetic and 3-hydroxybutyric acids dissociate at body pH and release H leading to a metabolic acidosis.
LCAT is the enzyme that esterifies the free cholesterol on HDL to cholesterol ester and allows the maturation of HDL.
LCAT deficiency does not allow for HDL maturation resulting in its rapid catabolism of circulating apoA-1 and apoA-2. The remaining form of HDL resembles nascent HDL.
