NEET PG Medical – 2018 – Question – 68
Which is the centrally acting alpha 2 agonist muscle relaxant –
a) Diazepam
b) Bromocriptine
c) Tizanidine
d) Methocarbamol
Show Answer
Correct Answer – C
Answer: -C- Tizanidine
Central alpha 2 adrenergic agonist Mechanism of action:
- Inhibits the release of excitatory amino acids in spinal interneurons
- Facilitates the inhibitory transmitter glycine
- Inhibits postsynaptic reflexes
- Reducing muscle tone, frequency of muscle spasms. Without reducing the strength of muscle.
Indications: - Spasticity in neurological disorders
- Painful muscle spasm of spinal origin.
Contraindications: - Patients on antihypertensive specially clonidine.
