NEET PG Medical – 2018 – Question – 58
What is mechanism of action of colchicine in acute gout?
a) Inhibition of purine metabolism
b) Inhibition of uric acid conversion
c) Migration of leukocytes
d) Leukocytes, lymphocytes inhibition & microtubular inhibitor
Show Answer
Correct Answer – D
Answer: D – Leukocytes, Lymphocytes migration inhibition & microtubular inhibitor.
Colchicine acts by inhibiting the granulocyte migration into the inflamed joint.
- An alkaloid from Colchicum autumnale
- Specifically suppresses gouty inflammation.
- Doesn’t inhibit the synthesis or promote the excretion of uric acid.
Mechanism of action: - Colchicine acts by, inhibits the release of glycoprotein
- Binds to fibrillar protein tubules inhibiting granulocyte migration into the inflamed joint.
- An acute attack of gout starts by precipitation of urate crystals in synovial fluid.
- Inflammatory response starts with granulocyte migration into joint
- Phagocytosing urate crystals releasing glycoprotein
- Glycoprotein increases lactic acid production and releasing lysosomal enzymes causing more joint destruction.
