NEET PG Medical – 2018 – Question – 53
Site of action of amphotericin B is:
a) Ribosomes
b) Cell wall
c) Plasma membrane
d) Protein
Show Answer
Correct Answer – B
Answer:- B – Cell wall
Polyene drug compounds like Amphotericin B acts on cell membrane –
- Amphotericin B, antifungal agent.
- Chemically a polyene compound Obtained from Streptomyces nodosus.
- Polyenes have a high affinity for “ergosterol” present in the fungal cell membrane.
- Binds and gets inserted into the cell membrane forming “Micropore”.
- Marked increase in permeability of cell membrane.
- Polyene drug compounds like Amphotericin B acts on cell membrane
- Amphotericin B, antifungal agent.
- Chemically a polyene compound
- Obtained from Streptomyces nodosus.
- Polyenes have a high affinity for “ergosterol” present in the fungal cell membrane.
- Binds and gets inserted into the cell membrane forming “Micropore”.
- Marked increase in permeability of cell membrane.
