NEET PG Medical – 2018 – Question – 12
Which receptors are blocked in Myasthenia Gravis?
a) Ach receptors
b) Ca++receptors
c) Na2+ receptors
d) Opioid receptors
Show Answer
Correct Answer – A
Answer: A – Ach receptors
An autoimmune disease
Antibody mediated autoimmune attack of acetylcholine receptors.
Inability of neuromuscular junctions to transmit signals from nerve to muscle
Resulting in muscle weakness and fatigability.
Unresponsive respiratory muscles may cause respiratory failure in severe cases.
Analysis of neuromuscular transmission reveal
- Decrease in acetylcholine receptors (AChRs)
- Loss of post-junctional folds.
- Circulating antibodies to acetylcholine receptors positive.
Diagnosis: - Clinical test: Strength improvement in response to administration of anticholinesterase agents.
Treatment: - Anti-cholinesterase drugs: Allows accumulation of larger amounts of acetylcholine in synaptic junctions.
- Neostigmine.
