NEET PG Medical – 2019 – Question – 57
What is the histological difference between them in Ulcerative colitis & Crohn’s disease?
a) Diffuse distribution of Pseudopolyps
b) Mucosal edema
c) Crypt abscess
d) Lymphoid aggregates in the mucosa
Show Answer
Correct Answer – C
differences between ulcerative colitis and Crohn’s disease are as follows:
| common site protective factor common risk factors risk factor T cell involved TH2 Wall involved Pseudopolyp type of ulcer cobblestone appearance skin lesions Creeping fat Granuloma Fistula  strictures Toxic megacolon seen Crypt abscess and destruction Rose thorn appearance metaplasia Renal calculi Extraintestinal manifestations Named criteria to assess the severity |
ulcerative colitis ileocolitis with rectal sparing no factors antibiotic during the first year of life, turner syndrome OCP, Smoking TH1 Transmural less common serpentine present seen seen non-caseating granuloma seen classical- perinatal (enterocutaneous) common not seen less marked seen Pyloric metaplasia is a clinical marker calcium oxalate uveitis, migratory polyarthritis, sacroiliitis, ankylosing spondylitis, erythema nodosum, clubbing, Primary sclerosing cholangitis ——– |
Crohns disease procolitis, rectum Smoking Appendicectomy antibiotic during the first year of life, turner syndrome α-Methyldopa, Wiskott– Aldrich Syndrome, TH2 mucosa & submucosa most common Collar-button ulcers not present not seen not seen  not seen not seen not common seen  more marked not seen  paneth cell metaplasia not present Similar to Crohn disease True Love Witt’s criteria-UC |
