NEET PG Medical – 2018 – Question – 47
Nude mice is not resistant to xenograft due to absence of
a) B cell
b) T cell
c) Both b and t cell
d) None
Show Answer
Correct Answer – B
Answer: B – T cell
Nude mice lacks “Thymus” & cannot generate mature T lymphocytes.
Absence of T-lymphocytes makes it unable to mount adaptive immune responses requiring CD4, helper T cells, CD8 and
cytotoxic T cells.
Adaptive immune responses that remain unresponsive to nude mice include:
- Antibody formation (CD4 + helper T cells)
- Cell-mediated immune responses (CD4+ and/or CD8+ T cells)
- Delayed-type hypersensitivity responses (CD4+ T cells)
- Killing of virus-infected or malignant cells (CD8 + cytotoxic T cells)
- Graft rejection (both CD4+ & CD8+ T cells)
Uses: - Laboratory study animal – Insights into immune system, leukemia, solid tumors, AIDS & other immune deficiency diseases.
- Absence of functioning T cells prevents them rejecting the allografts & Xenografts.
