NEET PG Medical – 2018 – Question – 34
Warthin finkeldey cells are seen in
a) Measles
b) Rubella
c) Rabies
d) Typhoid
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Correct Answer – A
Answer: A. Measles
Multinucleated cells like Warthin Finkeldey are seen in Measles
- Measles virus infects by invasion of respiratory epithelium.
- Local multiplication leads to viremia (day 2-3), then spread to RE system.
- Two types of Multinucleated giant cells in both epidermis & oral epithelium by 7-11 days.
- Warthin Finkeldey cells of reticuloendothelial system
- Epithelial giant cells of respiratory & other epithelia.
- Warthin–Finkeldey cell:
- Type of giant multinucleate cell found in hyperplastic lymph nodes early in the course of measles
- Under the light microscope, these cells consist of a large, grape-like cluster of nuclei.
- Also with HIV-infected individuals and Kimura disease .
- Rarely in neoplastic (e.g. lymphoma) & non-neoplastic lymph node disorders.
- Unknown origin; Reports of staining with markers similar to follicular dendritic cells, including CD21.
