NEET PG Medical – 2018 – Question – 32
Fibrinopeptide A and fibrinopeptide B are acidic due to the presence of which amino acids in its structure –
a) Serine and threonine
b) Glutamate and aspartate
c) Histidine and lysine
d) Glutamine and valine
Show Answer
Correct Answer – B
Answer: B. Glutamate and aspartate
The N-terminal A and B portions of the Aα and Bβ chains are termed fibrinopeptide A (FPA) and fibrinopeptide B (FPB), respectively.
These domains are highly negatively charged as a result of an abundance of aspartate and glutamate residues.
The negative charges contribute to the solubility of fibrinogen in plasma and importantly also serve to prevent aggregation by causing electrostatic repulsion between fibrinogen molecules.
