NEET PG Medical – 2019 – Question – 34
Which of the following is not the source of cytosolic NADPH ?
a) Isocitrate dehydrogenase
b) ATP citrate lyase
c) Malic enzyme
d) G6PD
Show Answer
Correct Answer – B
Answer. B. ATP citrate lyase
NADPH is a cofactor used in anabolic reactions, such as lipid and nucleic acid synthesis, which require NADPH as a reducing agent.
The major source of NADPH in animals and other nonphotosynthetic organisms is the pentose phosphate pathway.
The key enzymes in these processes are: NADP-linked malic enzyme, NADP-linked isocitrate dehydrogenase, NADP-linked
glutamate dehydrogenase and nicotinamide nucleotide transhydrogenase.
